Formulation and Evaluation of Multi-particulate Drug Delivery System for Metformin Hydrochloride by Spray Drying Method

Diabetes mellitus is a serious emergency right now which is considered to be one of the major causes of death in all the nations. MET is considered to be one of the major medications to treat type two or insulin dependent diabetes mellitus. Though this process of oral administration may reduce the level of glucose in the blood, it shows some adverse effect on the kidney. In the presented work, a successful attempt has been taken to formulate the multiparticulate drug delivery system for MET prepared by spray drying technique. The study of the In-vitro release profile of spray dried particles produces the desired release profile for SR of MET. The proposed formulations have an excellent floating property which is predictive for gastro retention of the proposed formulation. It was found that concentration of Carbopol 934 and ethyl cellulose affect over the few variables. The desired release of MET was achieved by adjusting the drug and polymer ration and the drug and (polymer: polymer ratio.) SEM studies reflected that the spray dried particles obtained from optimized batch and optimized process parameters have good surface morphological characteristics.