Nipah Virus: A Threatening Outbreak

Nipah Virus (NiV) first identified in Malaysia in 1998, was found to be a highly pathogenic re-emerging paramyxovirus able to produce febrile encephalitis and respiratory sickness for which there are no vaccinations or approved therapies present. Pteropus species bats act as the main natural reservoir. NiV comes under level-4 in biosafety and most commonly spreads through Pteropus fruit bat saliva or excrement, or through close contact with intermediate hosts such as pigs. This virus is predominantly common in Southeast Asia and is considered one of the deadliest viruses in the world with the highest mortality rates. Different strains of the virus were found to display different epidemiological and clinical features. In order to contain outbreaks, quick diagnosis and infection control measures are needed. For diagnosis and surveillance, varieties of serological and molecular diagnostic approaches have been developed. Here, the authors review the current concepts in NiV genome, structure, replication, epidemiology, different viral strains, pathogenesis, clinical signs and symptoms, diagnosis, treatment, vaccines and prevention in human beings.