Efficacy of Different Doses of 1% of 2-Chloroprocaine in Spinal Anaesthesia for below Umbilicus Surgery: A Randomised Clinical Trial

Introduction: A 2-chloroprocaine is a short acting amino-ester group of local anaesthetic drug used in spinal anaesthesia. The dose of 30 mg of 1% 2-chloroprocaine can also be used for below umbilicus surgery.

Aim: To compare the efficacy of two doses of 1% of 2-chloroprocaine in spinal anaesthesia for below umbilicus surgery.

Materials and Methods: This prospective randomised clinical trial was conducted from December 2019 to April 2020, on 32 patients who were allocated into two groups. Group A received 30 mg of 1% of 2-chloroprocaine and group B received 40 mg of 1% of 2-chloroprocaine for spinal anaesthesia. Onset of motor and sensory block, peak block height and haemodynamic parameters were noted in the intraoperative period. Recovery from spinal anaesthesia was noted and transient neurologic symptoms were also noted after 24 hours and seven days after surgery. Mean and standard deviations were calculated from the collected data and Statistical Package for Social Sciences (SPSS) version 20.0 was used for the analysis.

Results: A total of 32 subjects (aged 20-60 years) were divided into group A (n=16; mean age: 31.56±10.05 years) and group B (n=16; mean age: 34.19±11.72 years). Time taken for the onset of sensory and motor block was similar in both the groups. The peak height reached was T8-T10 in group A and T6-T10 in group B. During recovery period, time taken for regression of sensory block were similar between the groups. Complete recovery from motor block took 75.69±10.78 minutes in group A and 93.53±8.96 minutes in group B which was statistically significant (p<0.001). Time taken for mobilisation without support was 113.85±25.50 minutes in group A and 119.87±13.42 minutes in group B (p=0.4115). There were no Transient Neurological Symptoms (TNS) in both the groups. All the patients were haemodynamically stable.

Conclusion: Both doses of 2-chloroprocaine can be used in day care surgery due to its short duration of action.