Selenomethionine: A Pink Trojan Redox Horse with Implications in Aging and Various Age-Related Diseases

Nasim, Muhammad Jawad and Zuraik, Mhd Mouayad and Abdin, Ahmad Yaman and Ney, Yannick and Jacob, Claus (2021) Selenomethionine: A Pink Trojan Redox Horse with Implications in Aging and Various Age-Related Diseases. Antioxidants, 10 (6). p. 882. ISSN 2076-3921

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Abstract

Selenium is an essential trace element. Although this chalcogen forms a wide variety of compounds, there are surprisingly few small-molecule organic selenium compounds (OSeCs) in biology. Besides its more prominent relative selenocysteine (SeCys), the amino acid selenomethionine (SeMet) is one example. SeMet is synthesized in plants and some fungi and, via nutrition, finds its way into mammalian cells. In contrast to its sulfur analog methionine (Met), SeMet is extraordinarily redox active under physiological conditions and via its catalytic selenide (RSeR’)/selenoxide (RSe(O)R’) couple provides protection against reactive oxygen species (ROS) and other possibly harmful oxidants. In contrast to SeCys, which is incorporated via an eloquent ribosomal mechanism, SeMet can enter such biomolecules by simply replacing proteinogenic Met. Interestingly, eukaryotes, such as yeast and mammals, also metabolize SeMet to a small family of reactive selenium species (RSeS). Together, SeMet, proteins containing SeMet and metabolites of SeMet form a powerful triad of redox-active metabolites with a plethora of biological implications. In any case, SeMet and its family of natural RSeS provide plenty of opportunities for studies in the fields of nutrition, aging, health and redox biology.

Item Type: Article
Subjects: Open Article Repository > Agricultural and Food Science
Depositing User: Unnamed user with email support@openarticledepository.com
Date Deposited: 17 Jul 2023 07:46
Last Modified: 02 Mar 2024 04:50
URI: http://journal.251news.co.in/id/eprint/1971

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