Tramadol Induced Ovarian and Uterine Changes in Albino Rats

Tramadol at the dose levels of 1mg and 3mg/100g body weight was administered to normal cycling rats for 20 days through intraperitoneal routes. At autopsy on 21st day significant reduction in the ovarian, uterine and body weight was observed. Histological observations showed decrease in the number and size of Graafian follicles, corpora lutea and increase in the atretic follicles in the ovary. The uterus showed absences of endometrial glands, decrease in the height of myometrium, endometrium and its epithelial cells. The total protein and glycogen content of the ovary and uterus is decreased whereas the cholesterol content is increased. The hypothalamo-hypophyseal gonadal axis is prominent regulator of reproductive activities in animals through neuro-endocrine regulation. In this study action of tramadol on ovary and uterine parameters is discussed.