Treatment with Omega-3 and L-Carnitine Improve Cardiac and Renal Complications in Metabolic Syndrome‐Induced Rats

Background: Frequent consumption of fructose and saturated fatty acids increase risk of metabolic syndrome (MS). Features of MS include insulin resistance, dyslipidemia, visceral obesity, and hypertension. The aim of this study was to investigate the role of Omega-3and L-carnitine in ameliorating features of MS.

Methods: Induction of MS in rats by high‐fructose high‐fat fed diet was certain after 8 weeks. Animals were divided into four groups: normal control, MS control group given saline, MS groups given Omega-3 (260 mg/kg), and L-carnitine (200 mg/kg) daily for 4 weeks. Blood pressure, heart rate, CK-MB, and lactate dehydrogenase (LDH) were estimated. Also, renal function and antioxidant activity were evaluated. In addition, to C-reactive protein (CRP), and fibrinogen determined.

Results: Omega-3and L-carnitine caused decrease in both ‐induced increase in blood pressure and heart rate. They reduced creatinine, blood urea nitrogen (BUN), uric acid, albumin, and malondialdehyde (MDA) with increased glutathione (GSH), and superoxide dismutase (SOD). Drugs also decreased CRP, and fibrinogen compared with MS control group.

Conclusion: Omega-3and L-carnitine ameliorate cardiac and renal complication of MS via their antioxidant activity.