An Assessment of Diabetes Amelioration Potentiality of Whole Extract of Heliotropium indicum in a Diet Mixed Dose-dependent Approach

Context: So many plants are reputed to possess diabetes ameliorating potentiality from ancient times. Some of those are proven as anti-diabetic. In contrast, the therapeutic potentiality of others is evidenced as either baseless or has not been proven yet under the light of in vivo analysis. Heliotropium indicum, grows roadside and wildly is also considered as anti-diabetic species in complementary and alternative treatment practice.

Objective: The aim of this study was to ascertain the therapeutic effects of Heliotropium indicum whole extract and figure out its safety profile to ameliorate diabetic conditions using the plant material.

Materials and Methods: Dried powder of Heliotropium indicum was dipped in ethanol. Next, extract was gathered after rotary evaporation. Alloxan monohydrate induced diabetic rats were treated with extract in a diet mixed manner.

Results and Discussion: Blood glucose levels were measured in both diabetic and non-diabetic rats over the course of the study. Upon measurement of blood glucose levels, all doses of Heliotropium indicum were found to decrease the elevated blood glucose levels in rats. However, only 750 mg/kg (p<0.05) reduces blood sugar levels. Thus, the average dose delivered the highest efficiency due to higher food and dose consumption.

Conclusion: The study concluded that metformin and leaf extract improved the diabetes-induced medical condition. It essentially shows that Heliotropium indicum extract could be used as a significant therapy for treating diabetes.