THE INFLUENCE OF DENTAL IMPLANTATION ON THE STATE OF THE BALANCE OF ANTIOXIDANTPROOXIDANT SYSTEM OF ORAL LIQUID IN PATIENTS WITH PARTIAL ADENTIA

Aim. The purpose of the study is to evaluate the influence of treatment of partial adentia by means of the dental implantation over the changes in antioxidant-prooxidant balance of oral liquid.

Materials and methods. The study was performed on 40 testees divided into 2 groups: the control group (conditionally healthy people) and the test group (patients with adentia of 1-4 teeth). During the initial examination all the testees underwent the sampling of oral liquid. The oral liquid of patients was sampled at three stages of treatment: at the suture release after the dental implantation, at the installation of the healing abutment and at the installation of orthopedic constructions. The concentration of the products of oxidative modifications of biomolecules was determined in oral liquid as well as the state of the system of antioxidant protection.

Results. As a result of a study, it was revealed that the antioxidant activity decreased by 20,7% against the background of the increase in intensity of oxidative processes in oral liquid of patients with partial adentia by 1,8 times. During the treatment it was revealed that the tendency of the gradual increase in general antioxidant potential to the control indices and the decrease in oxidative stress in oral liquid took place. The activity of superoxide dismutase and catalase in oral liquid of patients of the 2nd group sampled at the initial examination was higher than the control indices by 71,6% and 53,4% respectively. At the second stage of the treatment the activity of superoxide dismutase remained increased by 59,1% while the catalase activity decreased by 2,4 times up to the indices 1,6 times lower than the control indices. At this stage it may be noted that the catalase insufficiency is relative which can lead to the increased concentration of hydrogen peroxide against the background of the increased activity of superoxide dismutase. At the 3rd and the 4th stages of the treatment the catalase activity increased by 25,9% in comparison with the indices of the previous stage of the study while the activity of superoxide dismutase decreased to the control indices. The correlation of changes in enzymatic activity of antioxidant protection was close to one.

Conclusion. The imbalance of antioxidant-prooxidant system at early stages of treatment may provoke the complications development that’s why the attention must be paid to the perspectives of possible antioxidant correction. In general, the results of the study proved the absence of negative influence of the material used in the dental implant on metabolic systems of oral liquid.