Management of Gastrointestinal Stromal Tumors: Experience of a University Hospital

Gastrointestinal stromal tumors or GISTs are rare tumors: 1 to 3% of malignant tumors gastrointestinal. 65% of these tumors sit in the stomach, 25% in the small bowel, 5-10% in the colon-rectum...

They occur secondary to activating mutations of the KIT or PDGFRA receptors. In 85% of cases, and are diagnosed at a localized stage in about 85% of cases. The spontaneous recurrence rate for patients who have undergone surgery and have a complete resection is approximately 40% at 10 years.

In this article we present a case of a gregarious stromal tumor whose age of occurrence was early and recurrence after complete surgical resection and targeted therapy was rapid and aggressive.

Also we discuss in the light of the literature, the results, surgical treatment, targeted therapy, histological findings and prognostic factors on which the risk of recurrence depends.