Significance of the astrocyte domain organization for qualitative information structuring in the brain

Mitterauer, Bernhard J. (2010) Significance of the astrocyte domain organization for qualitative information structuring in the brain. Advances in Bioscience and Biotechnology, 01 (05). pp. 391-397. ISSN 2156-8456

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Abstract

Astrocytes, the dominant glial cell type, modulate synaptic information transmission. Each astrocyte is organized in non-overlapping domains. Here, a formally based model of the possible significance of astrocyte domain organization is proposed. It is hypothesized that each astrocyte contacting n neurons with m synapses via its processes generates dynamic domains of synaptic interactions based on qualitative criteria so that it exerts a structuring of neuronal information processing. The formalism (morpho-grammatics) describes the combinatorics of the various astrocytic receptor types for occupancy with cognate neurotransmitters. Astrocytic processes are able both to contact synapses and retract from them. Rhythmic oscillations of the astrocyte may program the domain organization, where clock genes may play a role in rhythm generation. For the interpretation of a domain organization a player of a string instrument is used as a paradigm. Since astrocytes form networks (syncytia), the interactions between astrocyte domains may be comparable to the improvisations in a jazz ensemble. Given the fact of a high combinational complexity of an astrocyte domain organization, which is formally demonstrable, and an uncomputable complexity of a network of astrocyte domains, the model proposed may not be testable in biological brains, but robotics could be a real alternative.

Item Type: Article
Subjects: Open Article Repository > Biological Science
Depositing User: Unnamed user with email support@openarticledepository.com
Date Deposited: 01 Apr 2023 05:58
Last Modified: 22 Jun 2024 08:07
URI: http://journal.251news.co.in/id/eprint/966

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